Hubert Selby, Jr., Requiem for a Dream, 1978

This story follows the lives of Sara Goldfarb, her son Harry, his girlfriend Marion Kleinmitz, and his best friend Tyrone C. Love, who are all searching for the key to their dreams in their own ways. In the process, they fall into devastating lives of addiction. Harry and Marion are in love and want to open their own business; their friend Tyrone wants to escape life in the ghetto. To achieve these dreams, they buy a large amount of heroin, planning to get rich by selling it.

Harry, Marion, and Tyrone become addicted to their own product. Eventually, when heroin becomes scarce, they turn on each other, slowly hiding the drugs they obtain from the other two members. On their way to Miami, Harry and Tyrone are arrested, convicted, and sentenced to jail. Harry's arm has become infected from repeated injections, and has to be amputated. Left alone, Marion becomes a prostitute to support her addiction. In jail, Tyrone faces frequent abuse from the guards due to his race. [Source]

Hubert Selby, Jr., Requiem for a Dream