Stan Lee and Steve Ditko, Amazing Fantasy #15, Introducing Spider-Man, 1962

It is impossible to imagine American popular culture without Marvel Comics. For decades, Marvel has published groundbreaking visual narratives that sustain attention on multiple levels: as metaphors for the experience of difference and otherness; as meditations on the fluid nature of identity; and as high-water marks in the artistic tradition of American cartooning, to name a few. [Source]

Amazing Fantasy #15, Introducing Spider-Man

Stan Lee and Steve Ditko